Recent Publications
2022:
Solvik TA, Nguyen TA, Tony Lin YH, Marsh T, Huang EJ, Wiita AP, Debnath J*, Leidal AM*. Secretory autophagy maintains proteostasis upon lysosome inhibition. J Cell Biol. 2022 Jun 06; 221(6). PMID: 35446347. PMCID: PMC9036093 *co-senior author.
Debnath, J, Leidal AM. Secretory Autophagy During Lysosomal Inhibition (SALI). Autophagy 2022.
Yang Y, Gomez M, Marsh T, Poillet-Perez L, Sawant A, Chen L, Park NR, Jackson SR, Hu Z, Alon N, Liu C, Debnath J, Guan JL, Davidson S, Verzi M, White E. Autophagy in PDGFRa+ mesenchymal cells is essential for intestinal stem cell survival. Proc Natl Acad Sci U S A. 2022 May 24; 119(21):e2202016119. PMID: 35537042
AACR Pathology Task Force. Pathology: Hub and Integrator of Modern, Multidisciplinary [Precision] Oncology. Clin Cancer Res. 2022 01 15; 28(2):265-270. PMID: 34893516 (Member of AACR Pathology Task Force)
Nguyen TA, Debnath J. Control of Unconventional Secretion By The Autophagy Machinery Control of Unconventional Secretion By The Autophagy Machinery. Curr. Opinion Physiol. 2022. Accepted for publication.
2021:
Marsh T, Tolani B, Debnath J. The Pleiotropic Functions of Autophagy in Metastasis. J. Cell Sci., 2021.134: jcs247056 doi: 10.1242/jcs.247056.
Nieto-Torres JL, Leidal AM, Debnath J*, Hansen M* Beyond autophagy: the expanding roles of ATG8 proteins. Trends Biochem. Sci., 2021, 46(8):673-686.
Tulpule A, Guan J, Neel DS, Allegakoen HR, Lin YP, Brown D, Chou YT, Heslin A, Chatterjee N, Perati S, Menon S, Nguyen TA, Debnath J, Ramirez AD, Shi X, Yang B, Feng S, Makhija S, Huang B, Bivona TG. Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules. Cell. 2021 Apr 08. PMID: 33848463
Li H, Doric Z, Berthet A, Jorgens DM, Nguyen MK, Hsieh I, Margulis J, Fang R, Debnath J, Sesaki H, Finkbeiner S, Huang E, Nakamura K. Longitudinal tracking of neuronal mitochondria delineates PINK1/Parkin-dependent mechanisms of mitochondrial recycling and degradation. Sci Adv. 2021 Aug; 7(32). PMID: 34362731. PMCID: PMC8346224
Kaur J, Goldsmith J, Tankka A, Eguiguren SB, Gimenez AA, Vick L, Debnath J*, Vlahakis A*. Atg32-dependent mitophagy sustains spermidine and nitric oxide required for heat-stress tolerance in Saccharomycescerevisiae. J Cell Sci. 2021 Jun 01; 134(11). PMID: 34096604. PMCID: PMC8214763 *co-senior author.
Leidal AM, Debnath J. Emerging roles for the autophagy machinery in extracellular vesicle biogenesis and secretion. FASEB Biosciences (Special Collection on Extracellular Vesicles). 2021, 3(5):377-386.
Rudnick JA*, Monkkonen T*, Mar FA, Barnes JM, Starobinets H, Goldsmith J, Roy S, Eguiguren SB, Weaver VM, Debnath J. Autophagy in stromal fibroblasts promotes tumor desmoplasia and mammary tumorigenesis. 2021. Genes and Development. 2021, doi:10.1101/gad.345629.120. PMID: 34168038.
Liu JY, Lin YT, Leidal AM, Huang HH, Ye J, Wiita AP, Debnath J. GRASP55 restricts early-stage autophagy and regulates spatial organization of the early secretory network. Biol Open. 2021 Sep 17. PMID: 34533192.
Rudnick J, Debnath J. Autophagy in host stromal fibroblasts supports tumor desmoplasia Autophagy 2021. 17(12):4497-4498.
2020:
Leidal AM, Huang HH, Marsh T, Solvik T, Zhang D, Ye J, Kai F, Goldsmith J, Liu JY, Huang YH, Monkkonen T, Vlahakis A, Huang EJ, Goodarzi H, Yu L, Wiita AP, Debnath J. The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles. Nat Cell Biol. 2020 Jan 13. PMID: 31932738. PMCID: PMC7007875
Leidal A, Debnath J. Unraveling the Mechanisms that Specify Molecules for Secretion in Extracellular Vesicles Methods, 2020. S1046-2023(19)30286-5.
Marsh T, Kenific CM, Suresh D, Gonzalez H, Shamir ER, Mei W, Tankka A, Leidal AM, Kalavacherla S, Woo K, Werb Z, Debnath J. Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression. Dev Cell. 2020 Feb 12. PMID: 32084360
Marsh T, Debnath J. Autophagy suppresses breast cancer metastasis by degrading NBR1. Autophagy 2020. 16(6):1164-1165.
Leidal AM, Debnath J. LC3-dependent extracellular vesicle loading and secretion (LDELS). Autophagy 2020. 6(6):1162-1163
Yamamoto K, Venida A, Yano J, Biancur DE, Kakiuchi M, Gupta S, Sohn ASW, Mukhopadhyay S, Lin EY, Parker SJ, Banh RS, Paulo JA, Wen KW, Debnath J, Kim GE, Mancias JD, Fearon DT, Perera RM, Kimmelman AC. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature. 2020 May; 581(7806):100-105. PMID: 32376951
Goldsmith J, Marsh T, Asthana S, Leidal AM, Suresh D, Olshen A, Debnath J. Ribosome profiling reveals a functional role for autophagy in mRNA translational control. Commun Biol. 2020 Jul 17; 3(1):388. PMID: 32681145. PMCID: PMC7367890
Nguyen TA, Debnath J. Unconventional secretion: cargo channeling by TMED10. Cell Research, 2020 July 17. 30(9): 713-714.
Zhang J, Velmeshev D, Hashimoto K, Huang YH, Hofmann JW, Shi X, Chen J, Leidal AM, Dishart JG, Cahill MK, Kelley KW, Liddelow SA, Seeley WW, Miller BL, Walther TC, Farese RV, Taylor JP, Ullian EM, Huang B, Debnath J, Wittmann T, Kriegstein AR, Huang EJ. Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency. Nature. 2020 Aug 31. PMID: 32866962.
Other Publications (before 2020):
Debnath J, Baehrecke EH, Kroemer G Does autophagy contribute to cell death? Autophagy. 2005 1: 66-74.
Debnath J, Brugge JS Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer. 2005 5: 675-88.
Hebner C, Weaver VM, Debnath J. Modeling Morphogenesis and Oncogenesis in Three-Dimensional Breast Epithelial Cultures. 2007. Annu Rev Pathol.
Chen GC, Lee JY, Tang HW, Debnath J, Thomas SM, Settleman J. Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation. Autophagy. 2008 Jan; 4(1):37-45. PMID: 17952025.
Fung C, Lock R, Gao S, Salas E, Debnath J. Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol Biol Cell. 2008 Mar; 19(3):797-806. PMID: 18094039.
Debnath J. Detachment-induced autophagy during anoikis and lumen formation in epithelial acini. Autophagy. 4: ,2008.
Lock R, Debnath J. Extracellular matrix regulation of autophagy. Curr Opin Cell Biol. 20: 583-8 , Oct/2008.
Kim SH, Debnath J, Mostov K, Park S, Hunt CA. A computational approach to resolve cell level contributions to early glandular epithelial cancer progression. BMC Syst Biol. 2009; 3:122. PMID: 20043854.
Kim SH, Park S, Mostov K, Debnath J, Hunt CA. Computational investigation of epithelial cell dynamic phenotype in vitro. Theor Biol Med Model. 2009; 6:8. PMID: 19476639.
N'Diaye EN, Kajihara KK, Hsieh I, Morisaki H, Debnath J, Brown EJ. PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation. EMBO Rep. 2009 Feb; 10(2):173-9. PMID: 19148225.
N'Diaye EN, Debnath J, Brown EJ. Ubiquilins accelerate autophagosome maturation and promote cell survival during nutrient starvation. Autophagy. 2009 May; 5(4):573-5. PMID: 19398896
Debnath J. Detachment-induced autophagy in three-dimensional epithelial cell cultures. Methods Enzymol. 452: 423-39 2009.
Kenific CM, Thorburn A, Debnath J. Autophagy and metastasis: another double-edged sword. Curr Opin Cell Biol. 22(2): 241-5. Nov/27/2009.
Chen N, Debnath J. Autophagy and tumorigenesis. FEBS Lett. 584:1427-35 Dec/24/2009.
Roy, S., Debnath J. Autophagy and tumorigenesis. Sem. Immunopath. June/30/2010.
Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease. PLoS One. 2010; 5(4):e9979. PMID: 20376313.
Gupta A, Roy S, Lazar AJ, Wang WL, McAuliffe JC, Reynoso D, McMahon J, Taguchi T, Floris G, Debiec-Rychter M, Schoffski P, Trent JA, Debnath J*, Rubin BP*. Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST). Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14333-8. PMID: 20660757. *co-senior author.
Radoshevich L, Murrow L, Chen N, Fernandez E, Roy S, Fung C, Debnath J. ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell. 2010 Aug 20; 142(4):590-600. PMID: 20723759.
Debnath J. p66Shc and Ras: Controlling anoikis from the inside-out. Oncogene. 29(41): 5556-8. Oct/14/2010.
Rubin BP, Debnath J. Therapeutic implications of autophagy-mediated cell survival in gastrointestinal stromal tumor after treatment with imatinib mesylate. Autophagy. 6(8): 1190-1, Nov/15/2010.
Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA. Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal. 2010; 3(147):ra81. PMID: 21062993.
Radoshevich L, Debnath J. ATG12-ATG3 and Mitochondria. Autophagy. 7(1): 109-11, 2011, Epub Nov/24/2011.
Lock R, Roy S, Kenific CM, Su JS, Salas E, Ronen SM, Debnath J. Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol Biol Cell. 2011 Jan 15; 22(2):165-78. PMID: 21119005.
Mirzoeva OK, Hann B, Hom YK, Debnath J, Aftab D, Shokat K, Korn WM. Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma. J Mol Med (Berl). 2011 Sep; 89(9):877-89. PMID: 21678117
Avivar-Valderas A, Salas E, Bobrovnikova-Marjon E, Diehl JA, Nagi C, Debnath J, Aguirre-Ghiso JA. PERK integrates autophagy and oxidative stress responses to promote survival during extracellular matrix detachment. Mol Cell Biol. 2011 Sep; 31(17):3616-29. PMID: 21709020.
Lock R, Debnath J. Ras, Autophagy and Glycolysis. Cell Cycle. 10(10): 1516-7, May/15/2011.
Debnath J. The multifaceted roles of autophagy in tumors-implications for breast cancer. J Mammary Gland Biol Neoplasia. 2011 Sep; 16(3):173-87.
Klionsky DJ, Baehrecke EH, Brumell JH, Chu CT, Codogno P, Cuervo AM, Debnath J, Deretic V, Elazar Z, Eskelinen EL, Finkbeiner S, Fueyo-Margareto J, Gewirtz D, Jäättelä M, Kroemer G, Levine B, Melia TJ, Mizushima N, Rubinsztein DC, Simonsen A, Thorburn A, Thumm M, Tooze SA. A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy (Multi-author consortium). 2011 Nov 1; 7(11):1273-94.
Thorburn A, Debnath J. Targeting chaperone-mediated autophagy in cancer. Sci Transl Med. 2011 Nov 16; 3(109):109ps45.
Lee HS, Daniels BH, Salas E, Bollen AW, Debnath J, Margeta M. Clinical utility of LC3 and p62 immunohistochemistry in diagnosis of drug-induced autophagic vacuolar myopathies: a case-control study. PLoS One. 2012; 7(4):e36221. PMID: 22558391.
Nedvetsky PI, Kwon SH, Debnath J, Mostov KE. Cyclic AMP regulates formation of mammary epithelial acini in vitro. Mol Biol Cell. 2012 Aug; 23(15):2973-81. PMID: 22675028.
Chen N, Eritja N, Lock R, Debnath J. Autophagy restricts proliferation driven by oncogenic phosphatidylinositol 3-kinase in three-dimensional culture. Oncogene. 2013 May 16; 32(20):2543-54. PMID: 22777351.
Avivar-Valderas A, Bobrovnikova-Marjon E, Alan Diehl J, Bardeesy N, Debnath J, Aguirre-Ghiso JA. Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK. Oncogene. 2013 Oct 10; 32(41):4932-40. PMID: 23160380.
Warr MR, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R, Debnath J, Passegué E. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature. 2013 Feb 21; 494(7437):323-7. PMID: 23389440.
Chen N, Debnath J. IkB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway. Autophagy. 2013 Aug; 9(8):1214-27. PMID: 23778976.
Murrow, L, Debnath, J. Autophagy as a Stress Response and Quality Control Mechanism: Implications For Cell Injury and Human Disease. Annu Rev Pathol. 2013, 8: 105-37.
Starobinets, H, Debnath, J. Cancer, a suppression switch, Nature. 2013, 504(7479):225-6.
Goldsmith, J, Levine, B., Debnath, J. Autophagy and cancer metabolism, Methods Enzymol. 2014; 542:25-57.
Damiano L, Stewart KM, Cohet N, Mouw JK, Lakins JN, Debnath J, Reisman D, Nickerson JA, Imbalzano AN, Weaver VM. Oncogenic targeting of BRM drives malignancy through C/EBPß-dependent induction of a5 integrin. Oncogene. 2014 May 8; 33(19):2441-53. PMID: 23770848.
Lock R, Kenific CM, Leidal AM, Salas E, Debnath J. Autophagy-Dependent Production of Secreted Factors Facilitates Oncogenic RAS-Driven Invasion. Cancer Discov. 2014 Apr; 4(4):466-79. PMID: 24513958.
Haller M, Hock AK, Giampazolias E, Oberst A, Green DR, Debnath J, Ryan KM, Vousden KH, Tait SW. Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity. Autophagy. 2014 Dec 2; 10(12):2269-78. PMID: 25629932.
Leidal, A, Debnath, J. "Doubling down" on the autophagy pathway to suppress tumor growth. Genes and Development. 2014; 28(11): 1137-9.
Amaravadi, R, Debnath, J. Mouse models address key concerns regarding autophagy inhibition in cancer. Cancer Discovery. 2014, 4: 873-75.
Malhotra R, Warne JP, Salas E, Xu AW, Debnath J. Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity. Autophagy. 2015 Jan 2;11(1):145-54. PMID: 25585051.
Murrow L, Malhotra R, Debnath J. ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. Nat Cell Biol. 2015 Mar 2; 17(3):300-10. PMID: 25686249.
Mar FA, Debnath J, Stohr BA. Autophagy-Independent Senescence and Genome Instability Driven by Targeted Telomere Dysfunction. Autophagy. 2015 Mar 9; 0. PMID: 25751002.
Salas E, Roy S, Marsh T, Rubin B, Debnath J. Oxidative pentose phosphate pathway inhibition is a key determinant of antimalarial induced cancer cell death. Oncogene. 2015 Oct 5. PMID: 26434592
Kimmey JM, Huynh JP, Weiss LA, Park S, Kambal A, Debnath J, Virgin HW, Stallings CL. Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection. Nature. 2015 Dec 9. PMID: 26649827.
Kenific, CM, Debnath J. Cellular and metabolic functions for autophagy in cancer cells. Trends Cell Biol. 2015, 25(1):37-45.
Marsh T, Debnath J. Ironing out Vps34 Inhibition. Nature Cell Biology 2015, 17(1):1-3.
Murrow, L, Debnath J. A Nuclear Option That Initiates Autophagy. Molecular Cell 2015, 57(3): 393-5.
Galluzzi L, Pietrocola F, Bravo-San Pedro JM, Amaravadi RK, Baehrecke EH, Cecconi F, Codogno P, Debnath J, Gewirtz DA, Karantza V, Kimmelman A, Kumar S, Levine B, Maiuri MC, Martin SJ, Penninger J, Piacentini M, Rubinsztein DC, Simon HU, Simonsen A, Thorburn AM, Velasco G, Ryan KM, Kroemer G. Autophagy in malignant transformation and cancer progression. EMBO J. 2015, 34(7): 856-8.
Murrow L, Debnath J. ATG12-ATG3 connects basal autophagy and late endosome function. Autophagy 2015, 11(6): 961-2.
Murrow, L, Debnath, J. ATG12-ATG3 coordinates basal autophagy, endolysosomal trafficking and exosome release. Molecular and Cellular Oncology. 2015.
Kaur J, Debnath, J. Autophagy at the crossroads of catabolism and anabolism. Nature Rev. Mol. Cell Bio. 2015, 16(8): 461-72.
Leidal A, Debnath J. Autophagy Devours the Nuclear Lamina to Thwart Oncogenic Stress. Developmental Cell 2015, 35(5):529-530.
Kenific CM, Stehbens SJ, Goldsmith J, Leidal AM, Faure N, Ye J, Wittmann T, Debnath J. NBR1 enables autophagy-dependent focal adhesion turnover. J Cell Biol. 2016 Feb 22. PMID: 26903539
Altshuler-Keylin S, Shinoda K, Hasegawa Y, Ikeda K, Hong H, Kang Q, Yang Y, Perera RM, Debnath J, Kajimura S. Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance. Cell Metabolism. 2016 Aug 24. PMID: 27568548
Starobinets H, Ye J, Broz M, Barry K, Goldsmith J, Marsh T, Rostker F, Krummel M, Debnath J. Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment. J Clin Invest. 2016 Oct 24. PMID: 27775547
Rose JC, Huang PS, Camp ND, Ye J, Leidal AM, Goreshnik I, Trevillian BM, Dickinson MS, Cunningham-Bryant D, Debnath J, Baker D, Wolf-Yadlin A, Maly DJ. A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics. Nat Chem Biol. 2016 Nov 21. PMID: 27870838
Kenific, CM, Wittman, T, Debnath J. Autophagy in adhesion and migration. J Cell Sci. 2016, 129(20):3685-3693.
Kenific CM, Debnath J. NBR1-dependent selective autophagy is required for efficient cell-matrix adhesion site disassembly. Autophagy. 2016 12(10):1958-1959.
Solvik, T, Debnath J. At the crossroads of autophagy and infection: Noncanonical roles for ATG proteins in viral replication. J Cell Biol. 2016. 214 (5): 503-5.
Vlahakis A, Debnath J. Triggering Selective Autophagy at the Right Place and the Right Time. Molecular Cell. 2016; 64(2):215-216.
Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A. The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells. Immunity. 2017 Mar 11. PMID: 28314591
Roy S, Leidal AM, Ye J, Ronen SM, Debnath J. Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake. Molecular Cell. 2017 Jun 06. PMID: 28602638
Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, Fimia GM, Fulda S, Gewirtz DA, Green DR, Hansen M, Harper JW, Jäättelä M, Johansen T, Juhasz G, Kimmelman AC, Kraft C, Ktistakis NT, Kumar S, Levine B, Lopez-Otin C, Madeo F, Martens S, Martinez J, Melendez A, Mizushima N, Münz C, Murphy LO, Penninger JM, Piacentini M, Reggiori F, Rubinsztein DC, Ryan KM, Santambrogio L, Scorrano L, Simon AK, Simon HU, Simonsen A, Tavernarakis N, Tooze SA, Yoshimori T, Yuan J, Yue Z, Zhong Q, Kroemer G. Molecular definitions of autophagy and related processes. EMBO J. (Multi-author expert consensus) 2017, 36(13):1811-1836.
Monkkonnen T, Debnath J. Inflammatory Signaling Cascades and Autophagy in Cancer Autophagy, 2017 16:1-9.
Roy S, Debnath J. Autophagy enables retromer-dependent plasma membrane translocation of SLC2A1/GLUT1 to enhance glucose uptake. Autophagy. 2017 13(11):2013-2014.
Chen SH, Jang GM, Hüttenhain R, Gordon DE, Du D, Newton BW, Johnson JR, Hiatt J, Hultquist JF, Johnson TL, Liu YL, Burton LA, Ye J, Reichermeier KM, Stroud RM, Marson A, Debnath J, Gross JD, Krogan NJ. CRL4AMBRA1 targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling. EMBO J. 2018 Aug 30. PMID: 30166453
Tan JMJ, Mellouk N, Osborne SE, Ammendolia DA, Dyer DN, Li R, Brunen D, van Rijn JM, Huang J, Czuczman MA, Cemma MA, Won AM, Yip CM, Xavier RJ, MacDuff DA, Reggiori F, Debnath J, Yoshimori T, Kim PK, Fairn GD, Coyaud E, Raught B, Muise AM, Higgins DE, Brumell JH. An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread. Nat Microbiol. 2018 Dec; 3(12):1472-1485. PMID: 30478389.
Cadwell K, Debnath J. Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. Journal of Cell Biology, 2018 217(3):813-822.
Commisso C, Debnath J. Macropinocytosis Fuels Prostate Cancer. Cancer Discovery 2018 8(7): 800-802.
Marsh T, Debnath J. WIPIng the Brakes off Autophagy Induction. Molecular Cell. 2018 72(2): 203-204.
Leidal, A, Levine, B., Debnath, J. Autophagy and the Cell Biology of Age-Related Disease. Nat. Cell Biol. 2018 20(12):1338-1348.
Amaravadi RK, Kimmelman AC, Debnath J. Targeting Autophagy in Cancer: Recent Advances and Future Directions. Cancer Discovery 2019 9(9):1167-1181.
