Recent Publications

S Roy, A Leidal, J Ye, S Ronen, and J. Debnath. .(2017). Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of Glut1 and Glucose Uptake.Molecular Cell.

Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A.(2017). The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagosome Induction and the Metabolic Transition of Activated T Cells. Immunity.

Rose JC, Huang PS, Camp ND, Ye J, Leidal AM, Goreshnik I, Trevillian BM, Dickinson MS, Cunningham-Bryant D, Debnath J, Baker D, Wolf-Yadlin A, Maly DJ.(2017). A computationally engineered RAS rheostat reveals RAS-ERK signaling dynamics. Nat Chem Biol.

Starobinets H, Ye J, Broz M, Barry K, Goldsmith J, Marsh T, Rostker F, Krummel M, Debnath J.(2016). Antitumor adaptive immunity remains intact following inhibition of autophagy and antimalarial treatment. J Clin Invest.

S Altshuler-Keylin, K Shinoda, Y Hasegawa, K Ikeda, H Hong, Q Kang, Y Yang, RM Perera, J Debnath, and S Kajimura (2016). Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance. Cell Metabolism.

CM Kenific, SJ Stehbens, J Goldsmith, AM Leidal, N Faure, J Ye, T Wittman, and J Debnath (2016). NBR1 enables autophagy-dependent focal adhesion turnover. Journal of Cell Biology.

E Salas, S Roy, T Marsh, B Rubin and J Debnath (2016). Oxidative pentose phosphate pathway inhibition is a key determinant of antimalarial induced cancer cell death. Oncogene.

FA Mar, J Debnath and BA Stohr (2015). Autophagy-Independent Senescence and Genome Instability Driven by Targeted Telomere Dysfunction. Autophagy.

R Malhotra, JP Warne, E Salas, AW Xu and J Debnath (2015). Loss of Atg12, but not Atg5, in pro-opiomelanocortin neurons exacerbates diet-induced obesity. Autophagy.

L Murrow, R Malhotra, J Debnath (2015). ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. Nature Cell Biology.


Recent Reviews

Vlahakis A and Debnath J.(2017). The Interconnections between Autophagy and Integrin-Mediated Cell Adhesion. J Mol Biol.

Vlahakis A and Debnath J.(2016). Triggering Selective Autophagy at the Right Place and the Right Time. Mol Cell.

T Solvik and J Debnath (2016). At the crossroads of autophagy and infection: Noncanonical roles for ATG proteins in viral replication. Journal of Cell Biology.

Kenific CM, Wittmann T, Debnath J.(2016). Autophagy in adhesion and migration. J Cell Sci.

Kenific CM, Debnath J.(2016). NBR1-dependent selective autophagy is required for efficient cell-matrix adhesion site disassembly. Autophagy.

DJ Klionsky, J Debnath et al (2016). Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy.

J Kaur and J Debnath (2015). Autophagy at the crossroads of catabolism and anabolism. Nature Reviews Molecular Cell Biology.

L Murrow and J Debnath (2015). ATG12–ATG3 connects basal autophagy and late endosome function. Autophagy.

L Galluzzi, J Debnath et al (2015). Autophagy in malignant transformation and cancer progression. EMBO J.

L Murrow and J Debnath (2015). A nuclear option that initiates autophagy. Molecular Cell.

T Marsh and J Debnath (2015). Ironing out VPS34 inhibition. Nature Cell Biology.

CM Kenific and J Debnath (2015). Cellular and metabolic functions for autophagy in cancer cells. Trends Cell Biol.


Other Publications

R Lock, CM Kenific, AM Leidal, E Salas, and J Debnath (2014). Autophagy dependent production of secreted factors facilitates oncogenic RAS-driven invasion. Cancer Discovery.

L Damiano, J Debnath, VM Weaver et al (2014). Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin. Oncogene

R Amaravadi and J Debnath (2014). Mouse models address key concerns regarding autophagy inhibition in cancer therapy. Cancer Discovery.

AM Leidal and J Debnath (2014). 'Doubling down' on the autophagy pathway to suppress tumor growth. Genes & Dev.

CM Kenific and J Debnath (2014). Cellular and metabolic functions for autophagy in cancer cells. Trends Cell Biol.

R Amaravadi and J Debnath (2014). Mouse models address key concerns regarding autophagy inhibition in cancer therapy. Cancer Discovery.

AM Leidal and J Debnath (2014). ‘Doubling down’ on the autophagy pathway to suppress tumor growth. Genes & Dev.

J Goldsmith, B Levine and J Debnath (2014). Autophagy and cancer metabolism.Methods Enzymol.

N Chan and J Debnath (2013). IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway. Autophagy.

H Starobinets and J Debnath (2013). News & Views: Cancer: A suppression switch. Nature.

MS Sosa, Bragado P, Debnath J, Aguirre-Ghiso JA (2013). Regulation of tumor cell dormancy by tissue microenvironments and autophagy. Adv Exp Med Biol.

MR Warr, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R, Debnath J, Passegue E (2013). FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature.

A Avivar-Valderas, Bobrovnikova-Marjon E, Alan Diehl J, Bardeesy N, Debnath J, Aguirre-Ghiso JA (2013). Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK. Oncogene.

N Chen, Eritja N, Lock R, Debnath J (2012). Autophagy Restricts Proliferation Driven By Oncogenic Phosphatidylinositol 3-Kinase in Three-Dimensional Culture. Oncogene.

P Nedvetsky, Kwon SH, Debnath J, Mostov KE (2012). cAMP Regulates Formation of Mammary Epithelial Acini In Vitro. Mol Biol Cell.

L Murrow, Debnath J (2012). Autophagy as a Stress Response and Quality Control Mechanism: Implications For Cell Injury and Human Disease. Ann Reviews Pathol: Mech of Disease.

HS Lee, Daniels BH, Salas E, Bollen AW, Debnath J, Margeta M (2012). Clinical Utility of LC3 and p62 Immunohistochemistry in Diagnosis of Drug-Induced Autophagic Vacuolar Myopathies. PLoS One. 7(4).

Thorburn A, Debnath J (2011). Targeting chaperone-mediated autophagy in cancer. Sci Transl Med.

J Debnath (2011). The Multifaceted Roles of Autophagy in Breast Cancer. J. Mamm. Gland Biol. Neopl. 16 (3): 173-87.

A Avivar-Valderas, Salas E, Bobrovnikova-Marjon E, Diehl JA, Nagi C, Debnath, J, and Aguirre Ghiso JA (2011). PERK integrates autophagy and oxidative stress responses to promote survival during ECM detachment. Mol. Cell Bio. 31(17): 3616-29.

DJ Klionsky, Baehrecke EH, Brumell JH, Chu CT, Codogno P, Cuervo AM, Debnath J, Deretic V, Elazar Z, Eskelinen EL, Finkbeiner S, Fueyo-Margareto J, Gewirtz D, Jäättelä M, Kroemer G, Levine B, Melia TJ, Mizushima N, Rubinsztein DC, Simonsen A, Thorburn A, Thumm M, Tooze SA (2011). A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy. 7(11): 1273-94.

OK Mirzoeva, Hahn B, Hom YK, Debnath J, Aftab, D, Shokat K, Korn, WM (2011). Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K - mTOR pathway in pancreatic adenocarcinoma. J Mol Med (Berl). 89(9): 877-89.

R Lock, Debnath J (2011). Ras, Autophagy and Glycolysis. Cell Cycle. 10(10): 1516-7.

R Lock, Roy S, Kenific CM, Salas E, Ronen, S, and Debnath, J (2011). Autophagy Facilitates Glycolysis During Ras Transformation. Mol. Biol. Cell. 22: 165-178.

L Radoshevich, Debnath J (2011). ATG12-ATG3 and Mitochondria. Autophagy. 7(1): 109-11.

BP Rubin, Debnath J (2010). Therapeutic implications of autophagy-mediated cell survival in gastrointestinal stromal tumor after treatment with imatinib mesylate. Autophagy. 6(8): 1190-1.

Q-W Fan, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA (2010) Akt and Autophagy Cooperate to Promote Survival of Drug-Resistant Glioma. Sci. Signal. 3: ra81.

A Gupta, Roy S, Lazar AJF, Wang W-L., McAuliffe JC, Reynoso D, McMahon J, Taguchi T, Floris G, Debiec-Rychter M, Schöffski P, Trent JA, Debnath J*, Rubin BP* (2010). Autophagy inhibition and anti-malarials promote cell death in gastrointestinal stromal tumor (GIST). Proc Natl Acad Sci USA. 107(32): 14333-48 (Direct Track II submission). *co-senior author.

L Radoshevich, Murrow L, Fernandez E, Chen N, Roy S, Fung C, Debnath J. (2010). ATG12 Conjugation to ATG3 Promotes Mitochondrial Homeostasis and Cell Death. Cell. 142(4): 590-600.

J Debnath. p66Shc and Ras: Controlling anoikis from the Inside-Out (2010). Oncogene. 29(41): 5556-8.

P Spilman, Podlutskaya N, Hart M, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V (2010). Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-ß Levels in a Mouse Model of Alzheimer's Disease. PLoS ONE. 1: e9979.

S Roy, Debnath J (2010). Autophagy and tumorigenesis. Sem. Immunopath. 32(4): 383-96.

C Kenific, Thorburn A, Debnath J (2010). Autophagy and Metastasis, Another Double Edged Sword. Curr. Opin. Cell Biol. 22: 241-245.

N Chen, Debnath J (2010). Autophagy and Tumorigenesis. FEBS Letters. 584:1427-35.

SHJ. Kim, Park S, Mostov K, Debnath J, Hunt, CA (2009). Computational Investigation of Epithelial Cell Dynamic Phenotype In Vitro. Theo. Biol. Med. Modeling. 6(1): 8.

EN N’Diaye, Debnath J, Brown, EJ (2009). Ubiliquins Promote Autophagosome Maturation and Cell Survival During Nutrient Starvation. Autophagy. 5(4): 573-75.

SHJ Kim, Debnath J, Mostov K, Park S, Hunt CA (2009). A Computational Approach to Resolve Cell Level Contributions to Early Glandular Epithelial Cancer Progression. BMC Systems Biology. 3: 122.

EN N’Diaye, Kajihara, K, Hsieh, I, Morisaki JH, Debnath J, Brown, EJ (2009). PLIC Proteins or Ubiquilins Regulate Autophagy-Dependent Cell Survival During Nutrient Starvation. EMBO Rep. 10(2): 173-79.

J Debnath (2009). Detachment-Induced Autophagy In Epithelial Cells Grown In 3D Culture. Methods in Enzymology. 452: 423-39.

R Lock, J Debnath (2008). ECM Regulation of Autophagy. Curr. Opin. Cell Biol.20:583-88.

J Debnath (2008). Detachment-Induced Autophagy During Anoikis and Lumen Formation In Epithelial Acini. Autophagy. 4(3): 351-3.

C Fung, R Lock, S Gao, E Salas, J Debnath (2008). Induction of Autophagy During Extracellular Matrix Detachment Promotes Cell Survival. Mol. Biol. Cell. 19: 797-806. (Highlighted as ASCB InCytes Paper)

GC Chen, Lee, JY, Tang, HW, Debnath, J, Thomas, SM, Settleman, J (2008). Genetic interactions between Drosophila melanogaster Atg 1 and paxillin reveal a role for paxillin in autophagosome formation. Autophagy. 4(1): 1-19.

D Klionsky et. al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes (2008). Autophagy. 4(2): 1-25.

C Hebner, Weaver VM, Debnath J (2008) Modeling Morphogenesis and Oncogenesis in Three Dimensional Breast Cultures. Ann. Reviews Pathol: Mech of Disease. 3: 313-39.

J Debnath, Fung C (2006). The Dual Roles of Autophagy in Cell Death and Survival. In Deretic, V. (Ed.): Autophagy In Immunity and Infection. Weinheim, Germany: Wiley-VCH. 105-121.

J Debnath, Baehrecke E, Kroemer G (2005). Does Autophagy Contribute to Cell Death? Autophagy. 1(2): e10-18.